Champion Health and Wellness Clinics

4295 San Felipe St., Ste. 235 Houston TX 77027

281-501-0611

Weight Management Consent

Disclaimer

This compounded medication contains Tirzepatide combined with Glycine and Vitamin B6, and is formulated specifically for individual patients who may not tolerate standard formulations or who require a customized therapeutic approach. It is prepared in accordance with Section 503A of the Federal Food, Drug, and Cosmetic Act and is dispensed solely pursuant to a valid patient-specific prescription from a licensed healthcare provider. Our compounded formulation is not affiliated with, endorsed by, or intended to replace the FDA-approved product manufactured by Eli Lilly. 

The addition of Glycine and Vitamin B6 is intended to support patients experiencing issues such as fatigue, muscle loss, or nausea-common concerns during weight loss or diabetes treatment-and may offer metabolic, neurological, and musculoskeletal benefits. This medication is not made for resale, bulk distribution, or office use, and is compounded exclusively to meet the clinical needs of individual patients when commercially available alternatives are not appropriate.

Purpose

Tirzepatide w/ B6 and Glycine* is one our most successful product for weight loss! With combined, dual acting appetite suppressing properties, our patients have found the most success. This product will change your life! 

We also add B6 and Glycine* to our Tirzepatide! Why? Because it's better!

B6 * is added to alleviate the nauseous side effects that Tirzepatide can have on some patients. B6 is added to our tirzepatide formula to help release stored carbohydrates so you can use them, which further aids in weight loss. B6 also helps convert amino acids into neurotransmitters so is beneficial in improving mood. Metabolic Enzyme Support: B6 is essential in protein metabolism and neurotransmitter production, supporting the body's energy production during weight loss and helping to preserve lean mass. B6 Helps convert food into energy. Supports the metabolism of proteins, carbohydrates, and fats May help regulate blood sugar levels, Reduces nausea and morning sickness, and promotes healthy skin and hair. 

Glycine* is an amino acid that has been shown to help maintain and retain muscle mass during weight loss. 

Comprehensive Scientific Overview

Subject: Enhancing GLP-1 RA Therapy: Mechanistic Rationale for Fixed-Dose Pyridoxine and Glycine

Our new compounded formula ons integrate fixed concentrations of Pyridoxine (B6) and Glycine with your

GLP-1 receptor agonists to address the two major challenges:

Nausea and Muscle Loss during Weight Reduction.

Formula on Breakdown:

• Tirzepatide Formula on: 25 mg/mL Tirzepatide + 50 mg/mL Pyridoxine (B6) + 20 mg/mL Glycine

• Semaglutide Formula on: 2.5 mg/mL Semaglutide + 50 mg/mL Pyridoxine (B6) + 20 mg/mL Glycine

Mechanistic Rationale:

• Pyridoxine(B6) (50 mg/mL):

  • Nausea Control: Vitamin B6 is a proven antiemetic. Studies in pregnancy have shown that doses as low as

    10–25 mg can significantly reduce nausea symptoms. With pyridoxine fixed at 50 mg/mL, even a 0.1 mL

    injection delivers ~5 mg B6 per 0.1ml—sufficient to reduce GLP-1–induced nausea as evidenced in clinical trials, while a maximum injection (0.96 mL for semaglutide or 0.6 mL for tirzepatide) delivers 48–30 mg far below toxic levels. Our fixed concentration delivers ~5 mg B6 per 0.1 mL and scales appropriately with dose escalation, ensuring effective nausea mi ga on without risk of overdose.

  • Metabolic Enzyme Support: B6 is essential in protein metabolism and neurotransmitter production, supporting the body’s energy production during weight loss and helping to preserve lean mass.

  • Safety : Even at the maximum volume, the delivered B6 remains well below the 100 mg/day upper limit, with toxicity only seen at chronic doses exceeding 200–500 mg/day.

  • With pyridoxine fixed at 50 mg/mL, even a 0.1 mL injection delivers ~5 mg B6—sufficient to reduce GLP-1 – induced nausea as evidenced in clinical trials, while a maximum injection (0.96 mL for semaglu de or 0.6 mL for tirzepatide) delivers 48–30 mg—far below toxic levels.

Glycine (20 mg/mL):

  • Muscle Preservation : Glycine has been shown to improve muscle protein synthesis and reduce inflammatory cytokine activity that contributes to muscle catabolism. Research indicates that glycine supplementation improves lean mass retention in weight loss scenarios.

  • Tolerability and Stability: Glycine fixed at 20 mg/mL provides ~2 mg per 0.1 mL and up to ~19–20 mg at the

    highest dose. This ensures an isotonic, supportive dose, ensuring injection comfort, that aids in muscle

    preservation without risk, given that therapeutic oral doses are in the gram range. Even at maximum doses,dd the total glycine exposure is minimal relative to safe oral doses used in clinical studies.

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